Hi John - THANK YOU so much for the great service you are doing. I notice that India now recommends hydroxychloroquine, which I thought was pretty much discredited. Any idea what is going on there? Is this just another example of India bungling the pandemic, or is there som e value there?
It does seem increasingly clear that vaccination largely prevents infection, not just symptomatic disease. But this seems to get conflated with the question of asymptomatic transmission. Obviously, no infection means no transmission. But how strong is the evidence that breakthrough infections, particularly asymptomatic breakthrough infections, are less transmissible?
If vaccination essentially eliminates, or at least greatly reduces, the risk of asymptomatic transmission, that's great. But does it?
In case you hadn't seen it -- super interesting new study of autoimmunity in COVID patients: https://www.nature.com/articles/s41586-021-03631-y
Hi John - THANK YOU so much for the great service you are doing. I notice that India now recommends hydroxychloroquine, which I thought was pretty much discredited. Any idea what is going on there? Is this just another example of India bungling the pandemic, or is there som e value there?
https://www.mohfw.gov.in/pdf/RevisedguidelinesforHomeIsolationofmildasymptomaticCOVID19cases.pdf
It does seem increasingly clear that vaccination largely prevents infection, not just symptomatic disease. But this seems to get conflated with the question of asymptomatic transmission. Obviously, no infection means no transmission. But how strong is the evidence that breakthrough infections, particularly asymptomatic breakthrough infections, are less transmissible?
If vaccination essentially eliminates, or at least greatly reduces, the risk of asymptomatic transmission, that's great. But does it?
And how do variants factor into all of this?
Happy Shavuot, enjoy your cheesecake and your vacation.
Doctor Leana Wen agrees with you about the mask thing: https://www.washingtonpost.com/opinions/2021/05/13/cdc-mask-rules-vaccination-leana-wen/
Dr. Wen is both a physician and a participant in a Janssen clinical trial (one vs. two doses).