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Jan 18, 2021Liked by John Skylar, PhD

The New York Times morning briefing quoted a New England Journal of Medicine vaccine FAQ (https://www.nejm.org/covid-vaccine/faq): “If there is an example of a vaccine in widespread clinical use that has this selective effect — prevents disease but not infection — I can’t think of one!"

That doesn't match my understanding from what you've said here. Can you think of any examples of vaccines that prevent disease without providing sterilizing immunity? If not, what is it about SARS-CoV-2 that makes you think our priors from previous vaccines might not apply?

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Jan 18, 2021Liked by John Skylar, PhD

Hey, John, have you written about antivirals? A diet of all vaccine essays is probably getting dull, and I find it disappointing that we still have no effective antiviral medications against SARS-CoV-2. (No, I don't think that remdesivir is actually doing anything.)

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